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questionable_content_feed) wrote2025-10-30 09:40 pm5691
personally I'd never ask someone about their pronouns like that, but Clinton is nosy
icanhascheezburger_feed) wrote2025-10-30 04:00 pm22 Purrfectly Spooky Memes of Cats Craving a Halloween Sweet Treat
Cats can't help but get a little curious when the Halloween candy comes out. The rustling wrappers, the sweet smells, the shiny colors… it's basically a feline sensory overload. Every pumpkin bucket becomes a treasure chest, and every candy bar suddenly looks like the world's most exciting toy.
While their humans are busy trading chocolate and caramel, these mischievous little meowsters are plotting their own kind of heist. One paw reaches out, a little nose sniffs closer, and before you know it, there's a kitty trying to steal a mini Snickers like it's a prize catch. They have no idea they can't actually eat it. They just want to be part of the fun.
Whether it's sitting in the middle of the candy stash or proudly batting a wrapped treat across the floor, cats just want in on Halloween's sweetest chaos. So while the hoomans enjoy their sugar rush, the felines will happily settle for cat treats, attention, and a front-row seat to all the spooky-season action.
icanhascheezburger_feed) wrote2025-10-30 03:00 pm'You’ve met the kitten that hangs around here': Couple finds a friendly stray outside their new apar
When a young cat started hanging around a new apartment complex, one couple couldn't help but take notice. At first, he seemed like a friendly neighborhood visitor. Social, sweet, and curious about everyone who walked by. But after a few days of seeing him wander alone and realizing no one claimed him, concern turned into care.
They started small, offering food, water, and a warm spot on their porch. Soon enough, the cat, now affectionately named Gary, began trusting them more, greeting them with purrs and choosing their company over the cold outdoors. He'd wander out during the day but always come back, sometimes tapping at the window for his nightly visit.
The couple plans to scan for a chip and post flyers just in case, but deep down, they know what's happening. Gary's not just passing through. He's home shopping. And it looks like he's already made his choice. With every meal, cuddle, and safe night inside, this once-stray sweetheart is settling into his new life and his new family.
icanhascheezburger_feed) wrote2025-10-30 02:00 pmAn Early Holiday Scroll of Christmas Cats All Too Eager for Santa's Sleigh
You might think cats and Christmas don't mix due to their capricious, destructive, and cunning nature. The Christmas tree is a common and understandable point of contention for cat owners. The lights, decorations, and beautifully wrapped boxes sitting pretty underneath the sprawling pine needles are all fair game for a mischievous kitty absolutely set on attacking everything you've worked so hard to prop up. Though it's barely Halloween, there are people (and cats) out there who simply need a taste of Christmas already. It's never too soon for the spirit of Christmas, the jolly caroling through the soft and wintery streets, the slowness of falling snow, and the cozy firelit cuddles with your kitty.
For Christmas and cat lovers alike, these adorable and premature Christmas cat memes are sure to get you into the holiday spirit. So when you're preparing your Christmas present list, your list of who's naughty and nice, and your Christmas cat meme scroll, enjoy these to set you in good spirits for the holidays.
icanhascheezburger_feed) wrote2025-10-30 01:00 pmA Purrfect Bundle of Cozy Cat Memes to Lull Listless Owners to Sleep
When you're in a sleepy, staid torpor of listless lulled energy, drifting between the pendulum swing of wakefulness and slumber, there's nothing better that will send you into a dreamy sleep than a simple cat scroll of wholesome and hilarious memes before bed. We can all be grateful for certain aspects of society and culture today, because one of the most valuable things to worship right now is sleeping. Think of our grandparent's generation, waking up at 5 in the morning to do manual labor as a child, and the fact that everyone thought that was normal and even prideful. These days, we can all take a step back from strenuous and unnecessary work for a little bit more leisure time.
More leisure time = more cat memes. More cat memes = more happiness. More happiness = better quality of life. So when you think about scrolling, there should never be associations of guilt or facile enjoyment, there can be feelings of real pleasure. So enjoy these sleeping kitties while you lull yourself to slumber.
icanhascheezburger_feed) wrote2025-10-30 11:00 am'I have no idea when he'll finally want to take responsibility for his cat': Highschooler agrees to
Hello, fellow feline pawrents - you know, you who parent cats, you who adopted a fluffy family member, you who are purroud to call your cat your "kitty kid". Because that's just how it is if you're a cat pawrent, it means you have a cat in your family that you take care of, that you protect, that you adore, that you provide for. That's kind of the starting condition of being, you know, a cat parent. You need to parent a cat.
Apparently, this is a fact not understood by some people. Don't believe us? Yeah, we wouldn't believe us either if we didn't read this next story. There's a person in the world who had the desire (the very benevolent one, we have to admit) to adopt a cat - so he chose a cat to adopt, and immediately gave her to a friend because he couldn't keep the kitten for many life troubles. He promised to provide for her, food, sand, toys - like a true cat pawrent should - but instead, he vanished into thin air. Ghosted the friend who agreed to keep his kitten safe in the meantime. When he does communicate, he says it might take him years until he can pick "his" cat up.
Can you believe it? We didn't either, in the beginning. This is ridiculous. You can't "adopt" a cat, but then expect someone else to take care of them, vet bills and all. Especially if the caretaker friend is still in high school. Did we mention this is a kid who takes up a responsibility like that, as a man? Yeah, the situation is complicated. But at least the cat is in good hands.
icanhascheezburger_feed) wrote2025-10-30 09:00 am28 Purrfect Posts Showing Potential Pawrents the Truly Hissterical Side of Cat Parenthood
Your life changes when you become a pawrent. You have something to look forward to after coming home from a long day at the office. Vacations are no longer desired to be endless; you crave coming home to be reunited with your fur baby. Even your schedule changes to revolve around making sure you spend enough quality time with them, and don't even get us started on mealtime. But it's not even those big things that make the purrfectly everlasting change that happens after you adopt your first cat child - it's all the silly memories that come after.
Every cat has their own unique purrsonality - and you'll quickly learn yours (you won't have a choice). They may prefer to drink out of your water glass rather than a bowl of water, they may use the toilet instead of the litter box, or you might find out that they have a hilarious addiction to watching the 90s cartoons. You can prepurr yourself for many parts of pawrenthood, but nothing can prepare you for the attachment you'll feel to your cat and how silly your life will be.
For all you potential pawrents looking to adopt, we've gathered some purrfect posts showing you the truly hissterical side of cat parenthood. It's not all sunshine and rainbows, but we can guarantee you that your life will never be boring ever again.
in_the_pipeline_feed) wrote2025-10-30 12:10 pmA Rare Silicon Switch
Here’s another example of an idea that has been kicking around for years in medicinal chemistry without ever really breaking through: substituting a silicon atom for a carbon. To be fair, most of the time this doesn’t seem to do all that much, while introducing various uncertainties around ADME and toxicity (since we don’t have all that much experience with organosilanes as drugs). So you can see why we’re not overrun with “silyl switch” compounds. But at the same time, there really do seem to be instances where it can help.
For instance, there was (is?) a camptothecin derivative, known variously as karenitecin, cositecan, or BNP1350, that had an alkylsilyl side chain that was claimed to help it be less prone to being removed by efflux pumps. As far as I can tell, this one has kicked around in a number of Phase I and II trials without ever advancing. And a silane analog of haloperidol did indeed show a different (and quite possibly beneficial) metabolic profile, but I don’t think that one even made it to the clinic. As I mentioned in that blog post linked in the first paragraph, I sent in a trimethylsilyl-for-t-butyl switch compound one time in an analoging program, and I have to say that the response from the project team was not a favorable one. But as often happens, there seemed to be no particular advantage to the TMS analog, so it didn’t become an issue, other than in the “Please don’t do that again” way.
This new paper (first link in the post) is a silyl-containing KIF18A kinesin inhibitor, which is class of compounds with several representatives, some of which are in the clinic already for susceptible cancers. Like the example mentioned above, this switch (a silapiperidine for plain piperidine) seems to have improved efflux stability. I’m not completely sure how this occurs, though - the silicon analogs are a big less hydrophilic, but what efflux transport proteins like and dislike is still a mystery to me (and no, not just to me!)
I find it hard to believe that “silicon slows down efflux pumping” will turn out to be a general rule, but I think it’s an idea that’s worth testing if your particular project is having that sort of trouble. Just be ready for some pushback! We’ll see if this compound (ATX020) advances. The company behind it (Accent Therapeutics) is calling it a “tool compound”, but we’ll see if they have the nerve (or the need!) to take a similar organosilane into human trials. . .
icanhascheezburger_feed) wrote2025-10-30 07:00 amMan rescues a tiny calico kitten from a pack of dogs that had her in their mouths in the middle of t
The life of a stray kitten is something so beyond complicated and difficult that we cannot even really imagine it. We know that they are out there, fighting for territory and food, but there are so many dangers out there for them beyond just that. Kittens are tiny and curious by nature, and the world is huge. It only takes a few wrong steps to suddenly lose momma cat somewhere on the street, and once a kitten is out there on its own, anything can happen.
We can only imagine how terrified this kitten must have been when she encountered this pack of dogs in the middle of the street, and when they took her and started playing with her, only to then drop her right in the middle of a busy road. Momma wasn't nearby to save her, but thankfully, someone else was. This man stopped his car and ran to her the second he realized that she was still alive. He saved her life, took her home, and adopted her, and if we can, then that's what we should all strive to do when we see an animal in need out there in the big scary world.
icanhascheezburger_feed) wrote2025-10-30 06:00 am24 Funny and Fabulous Feline Memes to Snuggle Up With on a Chilly Fall Day
It's finally chilly outside, and we don't know about you, but this is our favorite time of year. Halloween is almost here, Christmas feels like it's right around the corner, hot cocoas are a staple every evening in our houses yet again, and we're just feeling the best that we have felt all year long. There's something in the air. Hope, maybe. For a better end to this year, a non-dramatic one, unlike what the rest of the year has felt. All that is missing for us right now, at this very moment, is something that will make us smile. And we have what you need right here - a whole bunch of purrfect cat memes.
These funny cat memes are not just any though. This collection of cat memes has been carefully curated by us to feel like a warm snuggle on a chilly fall day. It makes you laugh just enough to warm you on the inside, it makes you smile, it makes you forget the drama for a second and just embrace the moment. It's purrfection.
icanhascheezburger_feed) wrote2025-10-30 12:00 pm25 Funny Feline Photos fur your Daily Dose of CBT - Cattitude Based Therapy
When it gets to this later point in the week, things start to feel fracking frustrating. And with all that pent-up energy sloshing around your soul, it can be incredibly tough to keep your mind focused and sharp on your work that you still need to get done. That is why we are proud to be introducing to you this collection of funny feline photos that will diligently deliver your much-needed daily dose of CBT - Cattitude Based Therapy.
A new form of feline therapy which harnesses the feisty feline energy that catalyses Cattitude, giving you a concentrated dose of dramatic attitude that you can use to ward off those who would displease, anger or distract you in your place of work. But be warned, this is some pretty powerful stuff, and looking at it for too long can cause feline fatigue, which is why we recommend following this with a collection of cute cat children to balance things out.
icanhascheezburger_feed) wrote2025-10-30 10:00 amNow That's Some Hissing Humor: 27 Cat Memes to Boost Your Spirits Until Halloween
Hello, fellow feline fans, it's the day before Halloween, that magical time when the air smells faintly of pumpkin spice, half the neighborhood is covered in fake cobwebs, and our cats are one spooky shadow away from accidentally scaring us to death. It's the almost Halloween mood - the excitement is bubbling, the costumes are ready (or maybe the cats have already shredded them), and we're just counting down the hours until spooky o'clock finally arrives.
But how do we pass the time until then? With cat memes, of course! Because let's be honest - cats and Halloween are kindred spirits. They're mysterious, dramatic, slightly chaotic, and occasionally seen sprinting across the room at invisible forces. You don't need ghosts when your cat already stares at walls like they're haunted.
So while we wait for trick-or-treaters to show up tomorrow and for our cats to knock over the pumpkin display for the fifteenth time, let's settle into the purrfect pre-Halloween tradition: scrolling through some hissing humor. These hissterical cat memes will boost your spirits, tickle your funny bone, and get you through that final spooky countdown in the most feline way possible. Because honestly - if Halloween is for witches and ghosts, today is for cat lovers and memes.
icanhascheezburger_feed) wrote2025-10-30 08:00 amBanana cat rejected from PetSmart Halloween trick-or-treat event because it was "only for dogs", pro
We love dogs (not as much as we love cats, obviously), but they do tend to dominate the pet world. It seems like every pet event is geared towards doggos, and we get it - dogs love going outside much more than cats. But what about us pawrents with cats who love to be social? With fluffy felines who like to go outside and pawticipate in events? On the rare occasions that we've taken one of our cats out with us, it was usually the dogs who couldn't behave around them. 99% of the time, it's not our cat who is the problem.
We, as pawrents, also love to show them off in their cute costumes. They love the attention they get while wearing them, and we would love to take them to a trick-or-treat event for pets, like the one below. However, we would be purrfectly peeved if we showed up with our cat in a cute costume, only to be turned away because they only expected dogs to show up. And that's exactly what happened.
A cute banana cat showed up at a local PetSmart trick-or-treat event, only to be turned away because the "pet" event was only meant for dogs. Well, cats are pets too, aren't they? They went home with a very disappointed kitty, and the cat community came to their aid by making a furrmal complaint to PetSmart and showing off all their cute costumed cats to make the sad banana feel better. See more kitties and drama below!
icanhascheezburger_feed) wrote2025-10-29 08:00 pmA Ray of Sunshine in the Form of 24 Fuzzy Feline Funnies (October 29, 2025)
When the world gets dark and gray, aim to tend to the light. The light in question? A ray of sunshine in the form of cat memes, of course!
Summer is definitely long gone… and so are the days of sunsets at 8 PM, shorts and t-shirts, and the warmth of the sun on our exposed skin. Everything must come to an end, but the changing of the seasons is a reminder that we will experience warmth again. We've kicked off fall, and with that comes a responsibility to ourselves and our favorite furry felines to remain in good spirits throughout the cold weather of autumn and winter. Most people dislike the frigid temperatures, but some of you find solace in the slow, calm energy that cold weather brings.
Even if all of you pet parents enjoy the cold weather, we all must get some vitamin D in somehow! Take your supplements and go for a stroll… and, (cough cough), look at some feline funnies that'll bring the color back to your cheeks and a smile on that purrfect face of yours! At the end of the day, we'd all rather be couch potatoes in temperatures under 50 degrees, so boosting our moods indoors is the next-best thing. Scroll below to get your day started with a smile.
icanhascheezburger_feed) wrote2025-10-29 07:00 pmHomeowner sets out a trap to catch a gopher, catches a feisty feline instead, decides to adopt the s
The cat distribution system works in mysterious ways; anyone who has ever had the chance of experiencing it in real life knows that. One thing we do know is that you almost never expect to be the recipient of the system, and the cat that you are distributed is always full of surprises.
The CDS story below is the purrfect example of how sometimes one gets handed a cat in an unexpected way. This homeowner set a trap out to catch a gopher, and instead they caught a beautiful cat, one that was definitely brought to them by the cat distribution system.
Naturally, as it was definitely not a gopher, they decided to free the sweet feline and welcome him into their home.
The cat, now named Skittles, is adjusting to his new home, and we couldn't have been happier for him and his new family for this exciting addition!
Keep scrolling to read the full story, and look at some awwdorable pictures of sweet Skittles and his family. After that, check out these hissterical cat memes special for the fall season.